Andersen, who suffered a season-ending injury over a month ago, was on the floor one last time as a member of the Greyhounds' starting lineup before being subbed out before first serve.
Maloney turned in nine kills with just two errors on 18 swings, and she added two service aces and tied her season-high with six total blocks for the Greyhounds.
Loyola went up five, 14-9, in the early going of the first set and led 19-14 after a Holy Cross attack error, forcing a Crusaders' timeout. The Greyhounds had an attack error of their own on the following point, giving Holy Cross a sideout point and starting a run that would see the Crusaders score five in a row to knot the set at 19-19.
The teams traded sideouts before a Mary Mullen gave the Crusaders a 21-20 advantage, and a follow-up kill by Alicia Swearingen pushed it to a two-point lead.
Loyola rallied from an early second-set deficit to lead, 16-15, after a Holy Cross attack error, but the Crusaders scored the next two points to regain the advantage. It would not lead by more than two points for the rest of the set, but Holy Cross scratched out a 2-0 match advantage with a 25-23 win.
In the third set, Loyola built a four-point advantage early that Holy Cross came back to force several ties after drawing even at 18-18.
Tied at 23-23, Holy Cross had a service error, and then Maloney and Molly Cichosz locked up a block on Mullen to win the set for Loyola and force the fourth frame.
Cichosz and Jane Lukas led all players with 16 kills each for the Greyhounds, while Emily Oliver recorded 13 and Mandy Sifferlen added 12 for the Crusaders.
The Greyhounds conclude their season next weekend with a pair of road matches, taking on Bucknell University and Colgate University Friday and Saturday.