The game was slow to start but with the score tied at five at 12:38, Loyola went on an 8-2 run to take a 13-7 lead at 8:36. Four different Greyhounds scored in the run with Tynisha Davis, Jill Glessner and Krystle Harrington scoring baskets while Lauren Troupe added two free-throws. Manhattan added two free-throws before Brittany Dunn maintained the lead with a jumper for a 15-9 score with 7:29 to play in the first. The Jaspers next two shots came from three-point range with a basket by Glessner between them for a 17-15 Loyola lead with 3:58 left. The Greyhounds scored the final 10-points of the half to take a 27-15 lead. Davis sparked the run scoring the first two baskets to take a 21-15 lead and Valderas added a third to take a 23-15 lead at 1:29. Harrington scored the last two baskets, both assisted by Troupe to take the 27-15 lead into the break.
The Jaspers came out of the break outscoring Loyola 8-2 to cut the lead to 29-23 with 17:17 left to play. The Greyhounds responded, going on a run of their own, outscoring the Jaspers 10-2 over the next six minutes to take their largest lead, 39-25. All five Loyola baskets came from different players. Manhattan cut that lead in half with another run, this time scoring nine points to the Greyhounds two. But Loyola maintained its composure and hitting 22-of-24 shots from the free-throw line over the final eight minutes of play while adding a basket each from Valderas and Dunn for the 66-57 final.
Harrington led the game with 16 points while Troupe added 13 and Dunn 12. Valderas added nine points and a team-high seven rebounds.
Gabrielle Cottrell led the Jaspers with 14 points, 12 from three-point range.
The Greyhounds move on to the semi-final round for the first time since 2001 and while face No. 2 seed Canisius at 2:15 at the Pepsi Arena.